Double pre-ß lipoprotein in ischaemic heart disease

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Abstract
The presence or absence of a double pre-.beta. lipoprotein (pre-.beta.1+ or pre-.beta.1-) peak on agarose gel electrophoresis was recorded in 77 survivors of myocardial infarction, their 1st-degree relatives and 148 controls. Thirty-nine percent of myocardial infarction survivors and 24% of controls had pre-.beta.1+ (P < 0.05). The segregation of pre-.beta.1+ in the families of myocardial infarction survivors was consistent with autosomal dominant inheritance. In the control group, fasting serum cholesterol and triglyceride values were higher in the pre-.beta.1+ subjects, but the differences were not significant. The presence of a double pre-.beta. lipoprotein peak on electrophoresis is apparently associated with an increased risk of myocardial infarction.