Proton relaxation enhancement of albumin, immunoglobulin g, and fibrinogen labeled with gd‐dtpa
- 1 January 1990
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 13 (1) , 38-43
- https://doi.org/10.1002/mrm.1910130106
Abstract
Bovine serum albumin, immunoglobulin G, and fibrinogen were labeled with Gd‐DTPA using a bifunctional chelating agent DTPA anhydride. The protein‐(Gd‐DTPA) conjugates had 1.4‐ to 2.0‐fold greater longitudinal relaxivities at 0.02 and 0.44 T than the relaxivity of plain Gd‐DTPA. The increase of longitudinal relaxivity was not directly related to the size of carrier protein. Up to 50 Gd‐DTPA chelates per protein, longitudinal relaxivity of the conjugates was proportional to the concentration of Gd and independent of the Gd/protein ratio.This publication has 22 references indexed in Scilit:
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