Determination of Phthalates in Water and Soil by Tandem Mass Spectrometry Under Chemical Ionization Conditions with Isobutane as Reagent Gas

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Abstract
Eleven phthalate esters spiked in water and soil were determined by tandem mass spectrometry (MS) under positive chemical ionization mass spectrometry (CIMS) conditions with isobutane as reagent gas. Emphasis was placed on the determination step because tandem MS and CIMS are not widely adopted in current methods of the U.S. Environmental Protection Agency. Extraction by sonica-tion and cleanup by use of a solid-phase extraction cartridge were adopted. The relative response factors gave relative standard deviations (RSDs) of 12-30% when 2 unlabeled internal standards were used. The relative abundances of monitored ions gave relative abundance deviations of less than ± 8%. The method confirms identity, including molecular weight, and quantitates with high specificity. Results obtained with 2 unlabeled internal standards were compared with results obtained with a stable-isotope-labeled internal standard for dioctyl phthalate.

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