Reduced Ocular Hypotensive Effect ot Topical β-Blockers in Glaucoma Patients Receiving Oral β-Blockers

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Abstract
We reviewed all the records of the Glaucoma Service at the Massachusetts Eye and Ear Infirmary (N = 1,700) to assess the ocular hypotensive effect of topical β-blockers in glaucoma patients receiving oral β-blocker therapy. We identified 27 patients with elevated intraocular pressure who were using systemic β-blockers before the initiation of topical β-blocker therapy and compared them with 28 control patients with elevated intraocular pressure who were not using oral β-blockers when a topical β-blocker was started. The intraocular pressure-lowering effect of topical β-blockers was shown to be significantly reduced in patients receiving oral β-blockers (p < 0.02). β-receptor selectivity of the oral and topical agents were found to be contributing factors in predicting the additive effect of topical β-blocker therapy during systemic β-blockade.

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