Methadone Pseudowithdrawal Syndrome: Paradigm for a Psychopharmacological Model of Opiate Addiction

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Abstract
The methadone pseudowithdrawal syndrome which mimics the opiate abstinence syndrome is described and noted to be associated with psychological stress. The nature of this observation is discussed and related to learning and conditioning. An interaction of these psychological factors with metabolic and pharmacologic processes is suggested. Supportive psychotherapeutic and expectant care has been found helpful in the management of the pseudowithdrawal syndrome.

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