Problems in Receptor Identification: Catecholamines

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Abstract
In the past few years much progress has been made in the identification of membrane-bound receptor structures for polypeptide hormones such as insulin, glucagon and ACTH, as well as for cholinergic receptors in the electric organ of fish and eels, glycine receptors in the spinal chord, and receptors for morphine and other opiate drugs in brain.1 These studies have been based on the selective binding of highly radioactive (1 to 2 Ci per millimole) hormone derivatives or drug antagonists to isolated cells or membrane preparations. Because all such methods of receptor identification depend only on the recognition or binding function . . .