THE EFFECT OF INDOMETHACIN ON THE PSYCHOMOTOR FUNCTION OF PATIENTS WITH RHEUMATIC DISEASES
- 1 June 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Rheumatology
- Vol. 27 (3) , 227-229
- https://doi.org/10.1093/rheumatology/27.3.227
Abstract
We have compared the effect of single and multiple doses of indomethacin and placebo on objective measurements of psychomotor impairment in patients. Following a single 50 mg dose (n = 8), indomethacin produced psychomotor disturbance in only those patients who had no recent history of NSAID exposure. After multiple doses of indomethacin (25 and 50 mg tid for 5 days), no significant psychomotor impairment was observed. We conclude that other NSAIDs may induce cross-tolerance to the psychomotor effects of indomethacin. Tachyphylaxis may develop to the psychomotor disturbance caused by indomethacin.Keywords
This publication has 1 reference indexed in Scilit:
- Side-effects of indomethacin.Annals of the Rheumatic Diseases, 1967