Haemoglobinopathy Screening in a ‘Low-Risk’ Area of the United Kingdom: South Glamorgan, Wales

Abstract
Figures collected over 2½ years of screening of women attending the antenatal clinics of South Glamorgan, Wales, showed that the percentage of women identified as at risk for haemoglobinopathy trait (7.4%) was almost twice that estimated from the 1981 Census data (4.1 %) and that the incidence of a thalas-saemia trait in these women (0.38% β; 0.68% α) was similar to that of an area of supposedly greater risk in London (0.46% β; 0.42% α). Figures from one laboratory showed that without a scrutiny of all antenatal clinic blood counts for thalassaemic indices some thalassaemia traits will be missed. The apparent incidence of the HbS trait was 0.13%, and reasons for this being an underestimate are given

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