Eliminated chromatin of Ascaris contains a gene that encodes a putative ribosomal protein.
- 1 March 1991
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 88 (5) , 1593-1596
- https://doi.org/10.1073/pnas.88.5.1593
Abstract
Chromatin diminution in the nematodes Parascaris equorum and Ascaris lumbricoides leads to the formation of somatic cells that contain less DNA than the germ-line cells. We present molecular evidence for the coding potential of germ-line-specific DNA. We report on a cDNA clone that codes for a putative ribosomal protein (ALEP-1, for A. lumbricoides eliminated protein 1). That the corresponding gene is located in the eliminated portion of the genome indicates a difference in germ-line and somatic ribosomes of A. lumbricoides and P. equorum. Elimination of the ALEP-1 gene from all somatic cells in its fully active state may represent an alternative way to gene regulation.Keywords
This publication has 26 references indexed in Scilit:
- Transcription in nematodes: Early Ascaris embryos are transcriptionally activeDevelopmental Biology, 1989
- Unusual kinetochores and chromatin diminution in ParascarisTrends in Genetics, 1989
- Optimal alignments in linear spaceBioinformatics, 1988
- Primary structures of three highly acidic ribosomal proteins S6, S12 and S15 from the archaebacterium Halobacterium marismortuiFEBS Letters, 1987
- Neither a germ line-specific nor several somatically expressed genes are lost or rearranged during embryonic chromatin diminution in the nematode Ascaris lumbricoides var. suumDevelopmental Biology, 1986
- Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomesCell, 1986
- Rapid and Sensitive Protein Similarity SearchesScience, 1985
- Point mutations close to the AUG initiator codon affect the efficiency of translation of rat preproinsulin in vivoNature, 1984
- Isolation of cloned DNA sequences containing ribosomal protein genes from saccharomyces cerevisiaeCell, 1979
- A general method applicable to the search for similarities in the amino acid sequence of two proteinsJournal of Molecular Biology, 1970