Lithium increases 5-HT-mediated neuroendocrine responses in tricyclic resistant depression
- 1 October 1989
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 99 (2) , 230-232
- https://doi.org/10.1007/bf00442813
Abstract
The addition of lithium to the tricyclic antidepressant medication of 11 depressed patients resulted in an increase in the prolactin response to l-tryptophan after both 4 days and 4 weeks of lithium treatment. There was also a significant fall in Hamilton Depression scores. The results suggest that lithium and tricyclic antidepressants may act synergistically to enhance certain aspects of brain 5-HT function in depressed patients.This publication has 15 references indexed in Scilit:
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