Diastereo- and Enantioselective Synthesis of β-Substituted γ,δ-Unsaturated α-Hydroxy-Ketones via [2,3]-Wittig Rearrangement of α-Allyloxyketone-Hydrazones
- 1 June 1995
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1995 (06) , 631-633
- https://doi.org/10.1055/s-1995-5013
Abstract
Asymmetric [2,3]-Wittig rearrangement of chiral hydrazones 2 affords α-hydroxy ketones 4 with various substituents in high enantiomeric excess and syn-diastereoselectivities, starting from readily available Weinreb-amides 1 in good overall yield.Keywords
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