Reversal of Respiratory Decline in Necrotic Liver Degeneration by Intraportal Antioxidants.

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Abstract
Summary The effects of intraportal injections of antioxidants on respiratory decline in dietary necrotic liver degeneration were investigated by comparing respiration of liver slices from rats before, and 30 minutes after injection. Several antioxidants (DPPD. San-toquin, Santoflex B, and di-tert-amlhydroquinone) were like α-tocopherol quite effective in the reversal of respiratory decline at doses of 1 mg or less, while others (NDGA. n-Propylgallate, BHA, Propylparasept, hydroquinone) were without any effect. Screening of 13 different compounds led with but few exceptions to the same scale of relative potencies as that obtained previously for protection against necrotic liver degeneration by feeding of the antioxidants in the necrogenic diet. Intraportal injection of 14.5 μg of DPPD was required to produce 50% reversal. On a molar basis, DPPD was twice as active as D, L-α-tocopherol. It is concluded that the protective effect against necrotic liver degeneration is not due to the prevention of autoxidation in the diet or in the gut; rather, it takes place within the organism itself.

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