Identification of a novel HLA‐B allele (B*4202) in a Saudi Arabian family with Behçet's disease
- 1 May 1997
- journal article
- Published by Wiley in Tissue Antigens
- Vol. 49 (5) , 526-528
- https://doi.org/10.1111/j.1399-0039.1997.tb02792.x
Abstract
A new HLA‐B antigen, tentatively called HLA‐B42AND, was identified as a B42 serologic variant in a Saudi Arabian family. DNA sequencing analysis of the second and third exon of this new B allele revealed that B42AND was identical to B*4201 except for a single T to C substitution at position 97 of exon 2. This substitution results in histidine (CAC) at codon 9 in B42AND instead of tyrosine (TAC) in B*4201. The antigen frequency of B42AND in a Saudi Arabian population was around 10%. This novel B42AND has officially been named HLA‐B*4202.Keywords
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