Central nervous system mediated stimulation by thyrotropin-releasing hormone of microcirculation in thyroid gland of rats.

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Abstract
The blood flow of thyroid, adrenal cortex and renal cortex in the pentobarbital anesthetized rat was assessed from hydrogen gas desaturation curves. Thyroid microcirculation was markedly augmented within 2 min after an intraventricular injection of thyrotropin-releasing hormone (thyroliberin, TRH) while met-enkephalin (ENK) failed to influence. Both TRH and ENK stimulated the microcirculation of adrenal cortex moderately. ENK diminished the renal cortex microcirculation whereas TRH did not exert any effect. The thyroid response to TRH was abolished by vagotomy; the existence of a specific TRH-vagus-thyroid connection evidently was indicated.