The biological action of substances related to thyroxine. 9. The effect of butyl 4-hydroxy-3:5-diiodobenzoate on the deiodination of triiodothyronine in the rat

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Abstract
Details are given for a method of preparation from 3:5-diiodo-L-thyronine of triiodothyronine labeled in the 3[image] position with I131. Radioactive triiodothyronine appears to be much more stable in solution at pH 8-9 than labeled thyroxine. The labeled compound was injected into rats with or without simultaneous administration of butyl 4-hydroxy-3:5-diiodobenzoate (BHDB), and the radioactivity of the excreta was measured. Administration of BHDB caused a marked reduction in the output of urinary iodide in intact rats after a single injection of labeled triiodo-thyronine at a number of different dose levels. This is interpreted as being due to interference with the deio-dination of this compound.