Epidemic Hemorrhagic Fever in Bolivia

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Abstract
Summary The 1962 epidemic of a febrile disease with hemorrhagic manifestations in Bolivia was apparently due to infection by a virus related to Junín virus, the etiological agent of Argentinian hemorrhagic fever. Laboratory evidence was obtained by complement fixation tests using the Junín antigen and sera from several small population groups in and around the epidemic areas of northeast Bolivia. Distribution and concentration of complement fixing antibody were related to recent illness, and serological conversion was demonstrated in the three pairs of sera available from typical cases of the Bolivian disease.