The Effect of Amitriptyline on Forearm Blood Flow
- 1 January 1976
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Clinical and Laboratory Investigation
- Vol. 36 (1) , 17-21
- https://doi.org/10.3109/00365517609068013
Abstract
The local effect of intra-arterial infusion of amitriptyline (AT) on forearm blood flow was studied in seven healthy subjects. AT was infused at rates of 0.05, 0.10, 0.15, and 0.20 mg · min−1 for periods of 5 min. Forearm blood flow showed a dose-dependent increase when the dose exceeded 0.10 mg · min-1. On the highest dose level the blood flow increased on an average by 73%. No systemic effects, as reflected by changes in heart rate, blood pressure, and blood flow in the contralateral forearm, were observed during the infusion. The present data indicate a dilatating effect of AT on resistance vessels possibly mediated by an α-adrenergic blockade.Keywords
This publication has 2 references indexed in Scilit:
- Cardiac Complications of Tricyclic Antidepressant TherapyAnnals of Internal Medicine, 1971
- ON PERIPHERAL PHARMACOLOGY OF AMITRIPTYLINE1965