Ultraviolet Mutagenesis in Bacteriophage T4 II. Photoreversal of Mutational Lesions

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Abstract
Drake, John W. (University of Illinois, Urbana). Ultraviolet mutagenesis in bacteriophage T4. II. Photoreversal of mutational lesions. J. Bacteriol. 92: 144–147. 1966.—T4 r mutations were induced by ultraviolet irradiation of extracellular phage particles, using a phage mutant, v , which is particularly susceptible to photoreactivation. Most of the induced r mutations could be subsequently photoreversed intracellularly with white light. Ultraviolet irradiation induces both transitions and sign mutations, and both were susceptible to photoreversal. The results suggest that two very different types of mutational lesions may arise from a common type of photochemical lesion.