RE: “COMBINED POSTMENOPAUSAL HORMONE THERAPY AND CARDIOVASCULAR DISEASE: TOWARD RESOLVING THE DISCREPANCY BETWEEN OBSERVATIONAL STUDIES AND THE WOMEN'S HEALTH INITIATIVE CLINICAL TRIAL”

Abstract
We appreciate the effort by Prentice et al. (1) to elucidate the basis for differences in the relation of postmenopausal hormone therapy to risk of coronary heart disease in observational studies and in the Women's Health Initiative (WHI) trial. Three findings from this and earlier WHI reports (2–4) are key.