Primary structure and expression of a functional human glucocorticoid receptor cDNA
- 19 December 1985
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 318 (6047) , 635-641
- https://doi.org/10.1038/318635a0
Abstract
Identification of complementary DNAs encoding the human glucocorticoid receptor predicts two protein forms, of 777 (α) and 742 (β) amino acids, which differ at their carboxy termini. The proteins contain a cysteine/lysine/arginine-rich region which may define the DNA-binding domain. Pure radiolabelled glucocorticoid receptor, synthesized in vitro, is immuno-reactive and possesses intrinsic steroid-binding activity characteristic of the native glucocorticoid receptor.This publication has 74 references indexed in Scilit:
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