Thermochemical studies of vitamin B12. Part II. Thermodynamic data for the interaction of imidazole and methylimidazoles with aquocobalamin (vitamin B12a)
- 1 January 1976
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in J. Chem. Soc., Dalton Trans.
- No. 3,p. 274-278
- https://doi.org/10.1039/dt9760000274
Abstract
Thermodynamic data (ΔG, ΔH, and ΔS) have been obtained for the reaction of imidazole, and 1-methyl-, 2-methyl- and 4(5)-methylimidazole with aquocobalamin in aqueous solution at 25 °C and in an ionic background of 0.1 mol dm–3[NO3]– ions. In addition, protonation equilibria for both the free and vitamin B12-complexed imidazoles have been investigated by a combination of potentiometric and spectrophotometric methods and direct microcalorimetry. The results are discussed.Keywords
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