VINYLOGOUS CARBINOLAMINE TUMOR INHIBITORS .9. ACTIVITY OF BIS-CARBAMOYLOXYMETHYL DERIVATIVES OF PYRROLES AND PYRROLIZINES AGAINST HUMAN-TUMOR XENOGRAFTS IN NUDE-MICE
- 1 January 1982
- journal article
- research article
- Vol. 42 (6) , 2168-2170
Abstract
The activities of the pyrrolizines, compounds 1 and 2, and the pyrroles, compounds 4 and 5, are reported in nude mouse-grown HT-29 human adenocarcinoma of the colon, DO 1 human oat carcinoma of the lung, and CL 1 human duct cell carcinoma of the breast (coded as CX-1, LX-1 and MX-1, respectively, by the National Cancer Institute [USA]). Compounds 2 and 4 were active against all 3 experimental tumors. Both compounds produced significant tumor regression in the human breast tumor xenograft and compound 4 caused tumor regression in the human lung tumor xenograft.This publication has 8 references indexed in Scilit:
- Current results of the screening program at the division of cancer treatment, national cancer institutePublished by Elsevier ,1981
- Vinylogous carbinolamine tumor inhibitors. 6. Synthesis and antileukemic activity of 1-methyl-2,5-diphenyl-3,4-bis(hydroxymethyl)-, 1,2,3-triphenyl-4,5-bis(hydroxymethyl)-, and 1-methyl-2,3-diphenyl-4,5-bis(hydroxymethyl)pyrrole bis(N-methylcarbamate)Journal of Medicinal Chemistry, 1980
- Vinylogous carbinolamine tumor inhibitors. 4. Antileukemic activity of derivatives of 1,2-dimethyl-3,4-bis(hydroxymethyl)-5-phenylpyrrole bis(N-methylcarbamate)Journal of Medicinal Chemistry, 1979
- REGRESSION OF HUMAN-TUMORS ESTABLISHED IN NUDE-MICE AFTER CONTINUOUS INFUSION OF THYMIDINE1979
- Vinylogous carbinolamine tumor inhibitors. 3. Antileukemic activity of derivatives of 1-phenyl-2,5-dimethyl-3,4-bis(hydroxymethyl)pyrrole bis(N-methylcarbamate)Journal of Medicinal Chemistry, 1977
- Synthesis and antileukemic activity of 5-substituted 2,3-dihydro-6,7-bis(hydroxymethyl)-1H-pyrrolizine diestersJournal of Medicinal Chemistry, 1977
- COMPARISON OF DRUG-METABOLIZING ENZYMES IN LIVER AND KIDNEYS FROM HOMOZYGOUS NUDE SWISS, HETEROZYGOUS NORMAL SWISS, HOMOZYGOUS NORMAL SWISS AND DBA/2 MICE1976
- New Human Tumor Cell LinesPublished by Springer Nature ,1975