Restoration of mutability in non-mutable Escherichia coli carrying different plasmids

1 January 1977

journal article
research article
Published by Springer Nature in Molecular Genetics and Genomics

Vol. 155 (3) , 287-290
https://doi.org/10.1007/bf00272807

Abstract

N and I group plasmids, which increase methylmethane sulfonate (MMS) mutagenesis in lexA ⁺ strains of E. coli WP2 may be divided into two classes: those restoring part of the mutability of lexA ^- strains (class I) and those leaving lexA ^- strains non-mutable (class II). Almost complete restoration of MMS mutability is obtained by class I plasmids in a partially suppressed lexA rnm strain, while class II plasmids cause far fewer MMS revertants in this strain than in lexA ⁺. A pair of class I and II plasmids in lexA ^- shows a synergistic effect on mutability. These two classes do not coincide with plasmid division into incompatibility groups.

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