ACTH Releasing Activity in vivo of a CRF Preparation and Lysine Vasopressin.
- 1 May 1959
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 101 (1) , 107-111
- https://doi.org/10.3181/00379727-101-24848
Abstract
CRF (corticotropin releasing factor) preparation fraction D (Guillemin, R. et al., Endocrinology 1957 v. 60, 488) stimulates release of ACTH in animals with a hypothalamic lesion or pharmacological blockade, at doses where the pressor equivalents as pure lysine vasopressin are inactive. The hypothysiotropic activity of fraction D observed in vitro is therefore confirmed in vivo and should be attributed to a substance different from vasopressin.Keywords
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