Studies on the pathogenesis of liver necrosis by α-amanitin. Effect of α-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver nuclei

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Abstract
Injection of [alpha]-amanitin to mice causes a decreased incorporation of [6-14C]-orotic acid into liver RNA in vivo. The activity of RNA polymerase activated by Mn2+ and ammonium sulphate is greatly impaired in liver nuclei isolated from mice poisoned with [alpha]-amanitin, and is inhibited by the addition of the same toxin in vitro. The activity of the Mg2+-activated RNA polymerase is only slightly affected by [alpha]-amanitin either administered to mice or added in vitro.