NEURONAL DEATH IN THE DEVELOPMENT AND AGING OF THE CEREBRAL CORTEX OF THE MOUSE
- 30 June 1983
- journal article
- research article
- Published by Wiley in Neuropathology and Applied Neurobiology
- Vol. 9 (4) , 297-311
- https://doi.org/10.1111/j.1365-2990.1983.tb00116.x
Abstract
The numbers of neurons and glial cells in the cerebral cortex of the mouse were estimated during its whole life-span (5-720 days), taking into account both the cellular densities of several areas and the cortical volumes. There is a massive neuronal loss in the cerebral cortex during early postnatal development, greater in layers II-IV than in layers V-VI. Aging is characterized by a discrete neuronal loss in the cerebral cortex, purely restricted to layers II-IV. The number of glial cells increases continuously from 5-720 days. The need to obtain volumetric measure together with cellular densities in order to get interpretable quantitative data on cellular death and proliferation is emphasized.This publication has 37 references indexed in Scilit:
- Cell death in the mammalian visual system during normal development: II. Superior colliculusJournal of Comparative Neurology, 1982
- Evidence for ganglion cell death during development of the Ipsilateral retinal projection in the ratDevelopmental Brain Research, 1981
- Naturally occurring neuron death in the optic layers of superior colliculus of the postnatal ratJournal of Neurocytology, 1980
- A COMPARATIVE QUANTITATIVE AND MORPHOLOGICAL STUDY OF AGEING IN THE MOUSE NEOSTRIATUM, INDUSIUM GRISEUM AND ANTERIOR COMMISSURENeuropathology and Applied Neurobiology, 1980
- A QUANTITATIVE LIFESPAN STUDY OF CHANGES IN CELL NUMBER, CELL DIVISION AND CELL DEATH IN VARIOUS REGIONS OF THE MOUSE FOREBRAINNeuropathology and Applied Neurobiology, 1979
- The time of origin and the pattern of survival of neurons in the isthmo‐optic nucleus of the chickJournal of Comparative Neurology, 1976
- Organization and development of brain stem auditory nuclei of the chicken: Ontogeny of N. magnocellularis and N. laminarisJournal of Comparative Neurology, 1976
- Architectonic map of neocortex of the normal mouseJournal of Comparative Neurology, 1975
- Cell death in the development of the lateral motor column of the chick embryoJournal of Comparative Neurology, 1975
- Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: An electron microscope studyJournal of Neurocytology, 1974