Renal functional effects of 2,4,5‐trichlorophenoxyacetic acid and silvex after acute and prolonged exposure

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Abstract
2,4,5-T and trichlorophenoxypropionic acid (silvex) are herbicides whose agricultural or industrial use might result in environmental contamination. Although the plasma half-life of acute doses less than 50 mg/kg is approximately 4.2 h, chronic administration of single daily doses of 20 mg/kg 2,4,5-T results in apparent accumulation of the herbicide. This result, coupled with the ability of these herbicides to inhibit the renal organic anion transport system, suggests that prolonged exposure could produce chronic or cumulative inhibition of renal anion transport. Cumulative effects should be observable as an enhanced effect of prolonged exposure compared with the effect of an acute dose.

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