Synthesis and anti-HIV activity of catanionic analogs of galactosylceramide
- 1 January 1999
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in New Journal of Chemistry
- Vol. 23 (11) , 1063-1065
- https://doi.org/10.1039/a905417k
Abstract
Two-chain and gemini catanionic analogs of galactosylceramide were easily prepared in quantitative yields, affording high anti-HIV activities with low cytotoxicities on human cells (e.g. for gemini 4b an EC50 of 0.5 µM with a CC50 of >100 µM were obtained).Keywords
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