A Missense Mutation of the Nitric Oxide Synthase (eNOS) Gene (Glu298Asp) in Five Patients with Coronary Artery Disease
- 1 August 1999
- journal article
- research article
- Published by SAGE Publications in Angiology
- Vol. 50 (8) , 671-676
- https://doi.org/10.1177/000331979905000808
Abstract
The authors report five patients with a missense mutation of the endothelial nitric oxide synthase (eNOS) gene (Glu298Asp) who have angiographically proven coronary artery disease (CAD). They compare their clinical findings and coronary arteriographic charac teristics. They conclude that these case reports show that this mutation is not solely responsible for development of CAD. Diabetes mellitus, smoking, and hyperlipidemia are other risk factors.Keywords
This publication has 21 references indexed in Scilit:
- Expression and Function of Recombinant Endothelial NO Synthase in Coronary Artery Smooth Muscle CellsArteriosclerosis, Thrombosis, and Vascular Biology, 1997
- Nitric oxide and cardiovascular diseasePostgraduate Medical Journal, 1997
- Enhanced Endothelium-Dependent Relaxations After Gene Transfer of Recombinant Endothelial Nitric Oxide Synthase to Rabbit Carotid ArteriesHypertension, 1997
- Diabetes-mediated decreases in ovarian superoxide dismutase activity are related to blood-follicle barrier and ovulation defects.Endocrinology, 1996
- Endothelial Nitric Oxide Production and Insulin SensitivityCirculation, 1996
- Hypertension in mice lacking the gene for endothelial nitric oxide synthaseNature, 1995
- Role of sympathetic nerve activity in the generation of vascular nitric oxide in urethane-anesthetized rats.Hypertension, 1991
- Nitric oxide and prostacyclin. Divergence of inhibitory effects on monocyte chemotaxis and adhesion to endothelium in vitro.Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 1991
- Role of endothelium-derived nitric oxide in the regulation of blood pressure.Proceedings of the National Academy of Sciences, 1989
- Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.Journal of Clinical Investigation, 1989