Skleromyxödem Arndt-Gottron und assoziierte Phänomene

Abstract
Scleromyxedema is an uncommon fibromucinous connective tissue disease characterized by accumulation of mucinous material in the dermis. A monoclonal paraprotein is regularly identified. A review of the literature (57 cases) shows the exceptional association of scleromyxedema with multiple myeloma (8.7%) and Waldenstrom macroglobulinemia (3.5%). A man with scleromyxedema, IgG lambda paraproteinemia, and sclerodactylia, as a special sign of scleromyxedema, is reported. Melphalan is the drug of choice in serious cases, but not effective in sclerodactylia.