Anti‐Pr3: Serological and Immunochemical Identification of a New Anti‐Pr Subspecificity
- 1 February 1976
- journal article
- Published by Wiley in Vox Sanguinis
- Vol. 30 (2) , 122-133
- https://doi.org/10.1111/j.1423-0410.1976.tb02802.x
Abstract
A monoclonal IgM(kappa) anti-Pr cold agglutinin occurring after a rubella infection is shown to have the 'new' anti-Pr subspecificity anti-Pr3. Pr3 determinants are found on cat and sheep erythrocytes which lack Pr1 and Pr2 determinants. By carbodiimide treatment of human erythrocyte glycoproteins, which causes intramolecular coupling of N-acetylneuraminic acid carboxyl groups and nucleophilic centers of the glycoprotein backbone, Pr3 antigen activity is strongly increased, while Pr1 and Pr2 determinants are inactivated.Keywords
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