Increased striatal glutamate transporter by repeated intermittent administration of methamphetamine
- 1 June 1996
- journal article
- Published by Wiley in Psychiatry and Clinical Neurosciences
- Vol. 50 (3) , 161-164
- https://doi.org/10.1111/j.1440-1819.1996.tb01682.x
Abstract
We have examined the immunoreactivities of a glutamate (Glu) transporter, GLT-1, in rat brains treated with a single or repeated intermittent administration of methamphetamine (MAP). In the stratum of behaviorally sensitized rate induced by repeated intermittent MAP treatment, GLT-1 immunoreactivities were increased by 51%. There was no difference in the GLT-1 immunoreactivities in all regions examined between rate treated with a single administration of MAP and the control rats. These results suggest that hyperglutamatergic activity in the striatum is involved in the induction of behavioral sensitization caused by MAP.Keywords
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