Absorption of Radioiron Perfused Through the Duodenum of the Rat

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Abstract
Retention and postabsorptive distribution of iron were studied by perfusing the small intestine of the rat at a constant rate with radioiron-ascorbate in a medium of known and constant composition in the absence of bile and pancreatic secretions. The intestine accumulated radioiron as long as perfusion was maintained (125 min.). The amount of iron retained varied considerably, from 3.79 to 9.35 µg, but the percentage distribution of the retained iron followed a consistent pattern during 18 hours following perfusion. The amount retained was related to both length of time that the intestine was exposed to perfused iron and weight of the intestinal segment. Increasing the amount of iron-binding globulin in blood to three times the normal levels by intravenous injection of iron-free siderophilin decreased the amount of iron accumulating in intestine and increased the rate at which iron entered blood. The total amount of retained iron increased to 1.5 times the mean retention of control animals. The increased retention was accounted for primarily by the enlarged iron-carrying capacity of the blood.

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