Effects of Pituitary Graft and 2-Bromo-α-ergocryptine on Mammary DNA Synthesis in Mice in Relation to Mammary Tumorigenesis2

1 May 1976

journal article
Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute

Vol. 56 (5) , 1055-1056
https://doi.org/10.1093/jnci/56.5.1055

Abstract

₃H-thymidine incorporation into mammary DNA as an index of mammary DNA synthesis in C3H/He virgin females was significantly higher at proestrus than at estrus and diestrus. The rise in incorporation at proestrus was completely blocked by the administration of 2-bromo-α-ergocryptine (Bromocriptin) 1 day before proestrus. The incorporation was maintained at a higher level than that at proestrus by pituitary grafts. The results supported the view that mammary DNA synthesis, which is stimulated by prolactin, is an important factor for mammary tumorigenesis.

Keywords

BLOCKED
VIRGIN
DIESTRUS
MAMMARY DNA SYNTHESIS
PITUITARY GRAFTS

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