The Neuropeptide Pituitary Adenylate Cyclase–Activating Polypeptide and Islet Function
- 1 September 2001
- journal article
- review article
- Published by American Diabetes Association in Diabetes
- Vol. 50 (9) , 1959-1969
- https://doi.org/10.2337/diabetes.50.9.1959
Abstract
The neuropeptide pituitary adenylate cyclase–activating polypeptide (PACAP) is ubiquitously distributed in both the central and peripheral nervous systems and exerts a variety of effects. PACAP is a neuropeptide in pancreatic islets, where it has been suggested as a parasympathetic and sensory neurotransmitter. PACAP stimulates insulin secretion in a glucose-dependent manner, by an effect executed mainly through augmenting the formation of cAMP and stimulating the uptake of calcium. Accumulating evidence in animal studies points to a physiological importance of PACAP in the regulation of the insulin response to feeding. This review summarizes the current knowledge of islet actions and mechanisms and the function of PACAP.Keywords
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