The Response of the Male Albino Rat to the Intraperitoneal Administration of Testosterone Propionate

Publisher Website
Google Scholar
Abstract
Sixty animals consisting of 15 groups of 4 respective litter-made brothers were used. Group 1, remained as uninjected controls; groups 2, 3, and 4 were injected intraperit. daily from 21 to 31 days of age with 1 mg., 100 [gamma] and 50 [gamma], respectively. Body wts. were taken before and after the expt. Twenty-four hrs. after the last inj. all animals were sacrificed, weighed and studied histologically. Body wt. showed a trend toward depression. Testes were inhibited in growth. Seminal vesicles and epididymides were stimulated All effects observed on the sex organs were statistically probably significant, the greatest effect being observed in the 1 mg. animals, the least effect occurring in the 100 [gamma] groups. The potency of testosterone propionate in all dosages used was sufficiently maintained after intraperit. adm. to result in significant responses in the 22-32 day old [male] albino rat.