Effects of antibiotics on the bactericidal activity of human serum
- 1 February 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 9 (2) , 141-148
- https://doi.org/10.1093/jac/9.2.141
Abstract
The interaction between several antibiotics and either normal human serum or EGTA-chelated Mg-treated serum has been tested. Synergism has been observed with rifampicin, tetracycline and doxycycline, but not with minocycline, aminoglycosides (kanamycin, tobramycin, gentamicin, sisomicin and amikacin), chloramphenicol, fosfomycin and erythromycin. It has been demonstrated that Escherichia coli K12 strains bearing plasmids, conferring resistance to tetracycline, were killed in the presence of serum. Evidence has been presented that this synergistic action depends on complement and can be abolished by serum treatment with ethyleneglycol-tetraacetic acid.Keywords
This publication has 2 references indexed in Scilit:
- The Significance of Serum-Sensitive Bacilli in Gram-Negative BacteremiaScandinavian Journal of Infectious Diseases, 1978
- Potentiation of Antibiotic Bactericidal Activity by Normal Human SerumAntimicrobial Agents and Chemotherapy, 1978