Adenoviruses Have Homology with a Reiterated Sequence in Genomic DNA
- 1 June 1984
- journal article
- research article
- Published by Mary Ann Liebert Inc in DNA
- Vol. 3 (3) , 223-230
- https://doi.org/10.1089/dna.1.1984.3.223
Abstract
The DNAs of human adenovirus types 2 and 5 (Ad2, Ad5) hybridize to genomic DNAs from human and chicken tissue. The pattern of Southern blot hybridization to genomic DNA digested with Eco RI suggests that sequences homologous to cloned Ad2 DNA are reiterated in genomic DNA. This was confirmed by liquid hybridization which shows that the hybrids have a low C0t1/2 value. Finally, we show that total genomic human DNA probes hybridize to short fragments of adenoviral DNA in early-region genes near the ends of the viral genome.This publication has 14 references indexed in Scilit:
- A biochemical investigation of the adenovirus-induced G1 to S phase progression: Thymidine kinase, ornithine decarboxylase, and inhibitors of polyamine biosynthesisJournal of Cellular Physiology, 1982
- Mechanism of activation of early viral transcription by the adenovirus E1A gene productCell, 1981
- Alterations to controls of cellular DNA synthesis by adenovirus infectionJournal of Virology, 1981
- Ubiquitous, interspersed repeated sequences in mammalian genomes.Proceedings of the National Academy of Sciences, 1980
- Analysis of human tonsil and cancer DNAs and RNAs for DNA sequences of group C (serotypes 1, 2, 5, and 6) human adenovirusesProceedings of the National Academy of Sciences, 1979
- Complex splicing patterns of RNAs from the early regions of adenovirus-2Journal of Molecular Biology, 1979
- Normal human tissues contain RNA and antigens related to infectious adenovirus type 2Nature, 1979
- Spliced early mRNAs of simian virus 40Proceedings of the National Academy of Sciences, 1978
- Some adenovirus DNA is associated with the DNA of permissive cells during productive or restricted growthJournal of Virology, 1978
- Efficient transcription of RNA into DNA by avian sarcoma virus polymeraseBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1976