Sucrochimie IV.1Synthèse régiosétective de dérivés aminés du saccharose via la réaction de Mitsunobu

Abstract
A convenient route for the regiosetective substitution of the primary hydroxyls of sucrose is reported. The application of Mitsunobu's procedure with phthatimide yields. without chromatographic separations, di- cr triphtha-timido derivatives substituted at the 6.6′ and 1′ positions of sucross. Simutta-neous formation of a 3′,4′ epoxide in the tagato configuration is observed. The corresponding aminodeoxysucroses are obtained by hydrazinolysis of those derivatives.