A CHANGE IN RABBIT FIBROMA VIRUS SUGGESTING MUTATION
Open Access
- 1 February 1936
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 63 (2) , 173-178
- https://doi.org/10.1084/jem.63.2.173
Abstract
A change in the type of lesion produced by the fibroma virus has been observed. At about its 18th serial transfer in domestic rabbits the virus lost its ability to induce fibromas when administered subcutaneously. Instead, lesions developing in either the subcutaneous tissue or in the testicle were predominantly inflammatory in character and partly composed of lymphocytes and large mononuclear cells in place of fibroblast-like cells. Andrewes, working with the same virus in England, has observed a somewhat similar change. Passage of my changed virus through cottontail rabbits results in a transient recovery of the capacity to produce fibromata, while similar passage of Andrewes' inflammatory virus is without effect.Keywords
This publication has 4 references indexed in Scilit:
- A CHANGE IN RABBIT FIBROMA VIRUS SUGGESTING MUTATIONThe Journal of Experimental Medicine, 1936
- A CHANGE IN RABBIT FIBROMA VIRUS SUGGESTING MUTATIONThe Journal of Experimental Medicine, 1936
- A TRANSMISSIBLE TUMOR-LIKE CONDITION IN RABBITSThe Journal of Experimental Medicine, 1932
- A FILTRABLE VIRUS CAUSING A TUMOR-LIKE CONDITION IN RABBITS AND ITS RELATIONSHIP TO VIRUS MYXOMATOSUMThe Journal of Experimental Medicine, 1932