Diastereoselective aldol reactions of β-silylenolates: a formal synthesis of thienamycin
- 1 January 1986
- journal article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 15,p. 1198-1199
- https://doi.org/10.1039/c39860001198
Abstract
The lithium enolate (1) of benzyl β-phenyldimethylsilylbutanoate reacts with β-phenyldimethylsilylpropionaldehyde (2) to give, with high diastereoselectivity, the aldol product (3), which is converted into the β-lactam (7), a known precursor of thienamycin.Keywords
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