Microbial Models of Mammalian Metabolism: Fungal Metabolism of the Diterpene Sclareol by Cunninghamella Species
- 1 March 1991
- journal article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 54 (2) , 483-490
- https://doi.org/10.1021/np50074a021
Abstract
Microbial metabolism of the diterpene sclareol was studied. Screening studies have shown a number of microorganisms capable of metabolizing sclareol. Preparative scale fermentation with Cunninghamella species NRRL 5695 has resulted in the production of two fungal metabolites that have been characterized as 3 beta-hydroxysclareol and 18-hydroxy-sclareol with the use of 2D nmr techniques. The yield of the two metabolites was improved by utilizing resting-cell suspensions of Cunninghamella species NRRL 5695.Keywords
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