Enantiocontrolled Total Synthesis of Conduritols:1(+)-Conduritol E and (-)-Conduritol F
- 1 September 1991
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1991 (09) , 645-646
- https://doi.org/10.1055/s-1991-20826
Abstract
Conduritols (+)-E, and (-)-F have been synthesized from bromobenzene in an efficient and enantiocontrolled fashion. Microbial oxidation of bromobenzene affords diene diol 2 [(1S,2S)-3-bromo-3,5-cyclohexadiene-1,2-diol] possessing the requisite cis-diol moiety of the above conduritols. Complete stereocontrol in the introduction of subsequent hydroxyls has been achieved.Keywords
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