Hypoglycemia in Hypertensive Diabetic Patients Treated with Sulfonylureas, Biguanides, and Captopril

Publisher Website
Google Scholar
Abstract
To the Editor: The need for early antihypertensive intervention in non-insulin-dependent diabetes (NIDDM) is becoming more and more accepted.1 In contrast to all other hypotensive agents, angiotensin-converting enzyme inhibitors exert a marginal beneficial effect on metabolic control in NIDDM2 , 3 that apparently does not increase the incidence of hypoglycemia in combination with sulfonylureas. The only anecdotal report of hypoglycemic episodes4 has not been confirmed by other investigators. We have seen two cases of unexpected hypoglycemia that developed when captopril was added to a regimen of sulfonylureas and biguanides for NIDDM.A 49-year-old woman with a 14-year history of diabetes, a 4-year . . .