Effects of Oxygen and Misonidazole on Cell Transformation and Cell Killing in C3H 10T1/2 Cells by X Rays in Vitro
- 1 October 1984
- journal article
- research article
- Published by JSTOR in Radiation Research
- Vol. 100 (1) , 96-103
- https://doi.org/10.2307/3576525
Abstract
The effects of O2 (air) and misonidazole on the transformation and killing of 10T/2 cells by X-rays were examined. The O2 effect for the cell transformation end point was very similar to that for cell killing. Misonidazole enhanced both cell killing and cell transformation to a similar extent. The enhancement of both end points by misonidazole occurred only in the absence of O2 during irradiation and was of lesser magnitude than that observed for O2. The radiation chemical processes leading to cell killing and cell transformation, respectively, are affected similarly by these 2 enhancers of radiation action.This publication has 5 references indexed in Scilit:
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