Increased purine nucleotide binding, altered polypeptide composition, and thermogenesis in brown adipose tissue mitochondria of cold-acclimated rats
- 1 June 1978
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry
- Vol. 56 (6) , 378-383
- https://doi.org/10.1139/o78-060
Abstract
Rapid increases in atractyloside-insensitive binding of purine nucleotides (ADP or GDP) and in a polypeptide of MW 32,000 occur in brown adipose tissue mitochondria of the rat during acclimation to cold. The increased binding is apparent within 1 h and reaches a maximum after 3-7 days of exposure to 4.degree. C. The increase in the MW 32,000 peptide occurs more slowly and reaches a maximum after 2-3 wk. There is a simultaneous decrease in a polypeptide of MW 96,000, apparent after 1 day and reaching a maximum after 1-2. The appearance of an increased amount of the purine nucleotide-sensitive proton conductance pathway was discussed in association with the development of an enhanced thermogenic capacity of brown adipose tissue mitochondria during acclimation of the rat to cold.This publication has 1 reference indexed in Scilit:
- Hamster Brown‐Adipose‐Tissue MitochondriaEuropean Journal of Biochemistry, 1976