IMMUNOSUPPRESSIVE EFFECTS OF SULFATO-TRANS-(-)-1,2-DIAMINOCYCLOHEXANEPLATINUM(II)

  • 1 January 1979
    • journal article
    • research article
    • Vol. 39  (9) , 3476-3478
Abstract
Sulfato-trans-(-)-1,2-diaminocyclohexane platinum (II) is a new antitumor agent. Its effect on immune responses was investigated. This agent inhibited lymphocyte transformation in response to phytohemagglutinin, pokeweed mitogen and concanavalin A. It inhibited antibody plaque-forming spleen cells in AKR/J mice at doses ranging from 2.5-7.5 mg/kg i.p. It also prolonged the survival of skin grafts against major histocompatibility barriers in C57BL/6J mice transplanted with tail skin from CBA/J mice. The effective dose ranged from 2.5-5 mg/kg. This compound inhibited graft-vs-host reaction in 3 wk-old AKR/J .times. DBA/2J F1 mice receiving spleen cells from AKR/J mice i.p. Significant inhibition of graft-vs-host reaction was seen with doses ranging from 1-7.5 mg/kg i.p. This drug is apparently immunosuppressive.

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