Differential regulation of polo-like kinase 1, 2, 3, and 4 gene expression in mammalian cells and tissues
- 10 January 2005
- journal article
- review article
- Published by Springer Nature in Oncogene
- Vol. 24 (2) , 260-266
- https://doi.org/10.1038/sj.onc.1208219
Abstract
The four mammalian polo-like kinase (Plk) family members are critical regulators of cell cycle progression, mitosis, cytokinesis, and the DNA damage response. Research conducted to date has primarily investigated the expression patterns, structural features, substrates, and subcellular distribution of these important serine-threonine kinases. Here, we review the published data describing the regulation of Plk1, 2, 3, or 4 gene expression either during mammalian cell cycle progression or in tissue samples. These studies have demonstrated that the Plk family genes are differentially expressed following growth factor stimulation of quiescent fibroblasts. Furthermore, although Plk1 and Plk2 mRNA and protein levels are coordinately regulated during cell cycle progression, this is not the case for Plk3. In addition, the Plk1, 2 and 4 proteins have relatively short intracellular half-lives, but Plk3 is very stable. The Plk family genes are also differentially regulated in stressed cells; for example, when DNA-damaging agents are added to cycling cells, Plk1 expression decreases, but Plk2 and Plk3 expression increases. Finally, Plk1, 2, 3, and 4 are expressed to varying degrees in different human tissue types and it has been reported that Plk1 expression is increased and Plk3 expression is decreased in tumor specimens. These results indicate that the differential regulation of Plk family member gene expression is one cellular strategy for controlling Plk activity in mammalian cells.Keywords
This publication has 55 references indexed in Scilit:
- Polo-like kinases and the orchestration of cell divisionNature Reviews Molecular Cell Biology, 2004
- Polo-like Kinase 1 (Plk1) Inhibits p53 Function by Physical Interaction and PhosphorylationJournal of Biological Chemistry, 2004
- Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cellsThe Journal of cell biology, 2004
- Radiation-Inducible hSNK Gene Is Transcriptionally Regulated by p53 Binding Homology Element in Human Thyroid CellsBiochemical and Biophysical Research Communications, 2001
- Sak Serine-Threonine Kinase Acts as an Effector of Tec Tyrosine KinasePublished by Elsevier ,2001
- Late mitotic failure in mice lacking Sak, a polo-like kinaseCurrent Biology, 2001
- A genome-wide survey of RAS transformation targetsNature Genetics, 2000
- Downregulation of Polo-like Kinase Correlates with Loss of Proliferative Ability of Cardiac MyocytesJournal of Molecular and Cellular Cardiology, 1997
- prk, a Cytokine-inducible Human Protein Serine/Threonine Kinase Whose Expression Appears to be Down-regulated in Lung CarcinomasPublished by Elsevier ,1996
- Identification by Targeted Differential Display of an Immediate Early Gene Encoding a Putative Serine/Threonine KinasePublished by Elsevier ,1995