Microcirculatory effect of serotonin on hemostasis following whole-body x-irradiation

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Abstract
The terminal vascular bed of the mesentery was examined in rats following exposure to relatively high doses of whole-body X-irradiation. The mesocecum was exteriorized (under anesthesia) at selected intervals between 3-30 days postirradiation. Vascular reactiv- ity and the status of the blood-tissue barrier were examined in conjunction with evidence for a hemostatic defect per se. Results indicate a sustained exaggerated response to epinephrine. The hemostatic defect could be counteracted by repeated serotonin injections starting on day 3 or 5 post irradiation; but a defect in the venular and capillary wall as demonstrated by topical application of Versene still remained. Neither intravascular thrombus formation following local injury, nor in vitro clotting time in both treated and untreated rats were correlated with platelet numbers.

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