INCREASING EFFECT OF CAFFEINE ON THE OXYGEN CONSUMPTION OF THE SKELETAL MUSCLE

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Abstract
The changes of metabolic activity in frog''s skeletal muscle at various concentrations of caffeine were studied in connection with the mechanical change of the muscle. At high concentrations of caffeine, mechanical change of the muscle was detected but the change in the oxygen consumption was negligible, while at low concentrations an increase in oxygen consumption but no mechanical change were observed. Not only in the K-depolarized muscle but also in the IAA-poisoned muscle caffeine increased the oxygen consumption as in the normal muscle. Caffeine did not stimulate the respiration of the muscle homogenates and the muscle mitochondria. Lactic acid content increased with increasing concentrations of caffeine. The CrP, ATP and ADP content decreased and inorganic phosphate increased with an increase in the concentration (maximum concentration less than 5mM) of caffeine.

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